
Nancy Guthrie Case: Glove DNA Yields No Hits
The cold case surrounding the 1975 murder of Nancy Guthrie, a Scottsdale mother, recently saw a significant investigative update. New DNA evidence extracted from a glove found at the crime scene has been meticulously re-analyzed, but unfortunately, it has not yet provided the breakthrough hoped for by authorities and the community.
The Enduring Mystery of Nancy Guthrie
Nancy Guthrie, a 28-year-old mother, was brutally murdered in her Scottsdale home on January 16, 1975. Her death has remained one of the most persistent unsolved mysteries in the Valley, leaving a lasting impact on her family and local residents. Despite extensive efforts by the Scottsdale Police Department over decades, the perpetrator has never been identified, and the case has transitioned into a complex cold case investigation.
Re-examining Key Evidence: The Glove DNA
New Hope Through Modern Forensics
In a renewed push to bring justice for Nancy Guthrie, investigators focused on a critical piece of evidence: a glove found near the crime scene. This glove, believed to belong to the assailant, was subjected to advanced DNA analysis, a technology far superior to anything available in the 1970s. The Scottsdale Police, in collaboration with the Arizona Department of Public Safety (DPS) crime lab and the FBI, undertook this re-examination, hoping to extract a viable DNA profile that could lead to an identification.
The CODIS Setback
The results of the re-testing revealed a DNA profile, a significant step in itself. This profile was then meticulously uploaded to the national Combined DNA Index System (CODIS), a database maintained by the FBI containing DNA profiles from convicted offenders, arrestees, and unsolved crime scenes across the country. However, after extensive searches, the DNA from the glove produced no matches, meaning the perpetrator’s profile is not currently present in this crucial national database.
Implications for a Cold Case
The absence of a CODIS hit is undoubtedly a disappointing development for investigators and the Guthrie family. It signifies that the individual responsible has likely not been previously arrested or convicted for a crime that led to their DNA being entered into CODIS. This often makes cold cases more challenging, as it eliminates one of the most direct pathways to identifying a suspect.
Despite this setback, the investigation is far from over. Law enforcement agencies in Arizona are increasingly utilizing investigative genetic genealogy (IGG) techniques, where DNA profiles are compared against public genealogy databases to find relatives of the unknown suspect. This is a growing strategy for cold cases when CODIS fails. Additionally, the preserved DNA sample remains a valuable asset for future technological advancements.
Modern Forensic Tools in Cold Cases
While the CODIS database is a powerful tool, the absence of a hit doesn’t mean the end of all investigative avenues. Other advanced techniques are increasingly vital in solving decades-old mysteries:
| Method | Primary Function | Outcome without a Hit |
|---|---|---|
| CODIS (Combined DNA Index System) | Matches DNA profiles from crime scenes to convicted offenders and arrestees in law enforcement databases. | Indicates the perpetrator’s DNA is not in official law enforcement databases. Requires alternative methods. |
| Investigative Genetic Genealogy (IGG) | Compares unknown DNA profiles to publicly available genealogy databases to find distant relatives, building family trees to narrow down suspects. | Can still identify a suspect or their relatives even if they have no criminal record, provided their family members have uploaded DNA to public sites. |
The strategic deployment of these varying techniques offers continued hope for cases like Nancy Guthrie’s, pushing beyond traditional forensic limitations.
Frequently Asked Questions About the Guthrie Case
- What is the Nancy Guthrie cold case?
The 1975 unsolved murder of Nancy Guthrie, a 28-year-old mother found deceased in her Scottsdale home, is a long-standing cold case in the Phoenix area. - What new evidence was re-tested?
DNA extracted from a glove found near the crime scene, believed to belong to the perpetrator, was recently subjected to modern forensic analysis. - Did the DNA re-test yield a suspect?
No, the DNA profile obtained from the glove was uploaded to the national CODIS database, but it did not produce any matches to known offenders. - Is the investigation still active?
Yes, despite the CODIS setback, the Scottsdale Police Department continues to actively investigate Nancy Guthrie’s murder, exploring other advanced forensic avenues.
While the latest DNA results from the glove haven’t provided the immediate breakthrough hoped for, they underscore the relentless dedication of Scottsdale police and forensic scientists in their pursuit of justice. For Phoenix locals, this ongoing effort is a reminder that cold cases are never truly forgotten, and every piece of information, no matter how small, can still make a difference in helping solve these enduring mysteries. If you have any information regarding Nancy Guthrie’s murder, please contact the Scottsdale Police Department.
Nancy Guthrie Case Glove DNA Yields No Hits


